We strongly recommend you to visit the new domain of STAM (https://atlas.brainsmatics.cn/STAM/) for secure and better performance. The current .org domain will be inactive in the future.

The brief introduction to STAM

The Stereotaxic Topographic Atlas of the Mouse Brain (STAM) is a three-dimensional topographical atlas that depict the anatomical structures of the whole mouse brain, achieving precise single-cell resolution localization. We employed a three-dimensional Nissl-stained image dataset with isotropic one-micron resolution as the basis, and created canonical anatomical sections through a projection with a thickness of 20 microns resolution for constructing the STAM that contains 916 brain structures, with reference to various auxiliary imaging data, including immunohistochemistry and specific gene type neuron distribution data. Here, we established the STAM visualization platform, which includes services for exploring two-dimensional canonical anatomical sections, three-dimensional topography, and arbitrary-angle slices of the brain atlas. The platform integrates different functionalities such as virtual surgery, and automatic registration of user-uploaded slices. The STAM is expected to provide an effective spatial localization benchmark for the registration and integration of results from single-cell level studies, such as multi-omics and neuronal circuitry.

Canonical plane visualization help

STAM's two-dimensional visualization service provides a digital map-style online browsing function with 700 coronal planes, 256 sagittal planes, and 367 horizontal planes.[More]

Stereotaxic topography visualization help

STAM's three-dimensional visualization service reconstructs the three-dimensional topography of 916 brain regions and nuclei.[More]

Arbitrary plane visualization help

We also offer the service of visualizing slices at arbitrary angles. Users can choose the angle of interest and examine the isotropic 1-micron resolution cytoarchitectural brain slice at that angle.

Automatic slice registration help

We provide an automatic brain slice registration service.[More]

Data sharing help

We provide open access and download services for the 3D cytoarchitecture image dataset of the whole mouse brain used for constructing STAM.[More]

Atlas mapping help

We support users in uploading 3D image data and neuronal morphology data previously registered to the Common Coordinate Framework (CCF).[More]

Virtual surgery help

We have developed a virtual surgery navigating service. [More]

Atlas reslicing help

This service provides the reslicing of atlas annotation images, generating canonical atlas planes, as well as arbitrary-angle plane. [More]

Neuronal circuits help

This service integrates neuron morphology data from multiple sources, by registering them onto STAM and then visualizing them in the 3D space of STAM. [More]