Mesoscale Morphological Subtyping and Spatiotemporal Evolution of Aβ Plaque Heterogeneity in the Whole Mouse Brain
Overview
This resource provides the data and code necessary to reproduce the findings reported in the paper. It includes: the imaging feature data and spatial localization information for all plaques across different age groups; as well as the complete analysis code.
Data Access
Plaque Information Dataset
The data are stored in CSV format, with each table containing aggregated plaque data for one age group. Plaque information includes the corresponding dataset ID, spatial coordinates, imaging features, brain region registration details, basic morphological classification, and subtype assignments under each feature group. Downloadable files available here:
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Plaque Information Summary
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Code Access
Plaque Feature Extraction
The code comprises three modules (including both 3D and 2D versions):
- Plaque feature construction
- Plaque foreground signal segmentation
- Plaque feature extraction
Plaque Classifications
The code comprises three modules:
- Feature selection within morphotypes
- Plaque morphological classification: for classifier construction, training, and prediction
- Plaque cluster analysis (including both 3D and 2D versions)
Plaque Analysis
The code comprises three modules:
- Post-processing: integrates dataset IDs, classifications, and spatial information
- Feature similarity analysis: computes similarities between different plaque types in feature space
- Distribution similarity analysis: compares spatiotemporal patterns across plaque types