PlaqueMap: An Interactive Database of Spatiotemporal Distribution for Diverse Aβ Plaque Types in the Whole Mouse Brain.
PlaqueMap is a comprehensive database of spatiotemporal distribution for different Aβ plaque types across the mouse brain. Constructed based on the 5XFAD mouse model and fMOST imaging technology, this database enables accurate single-plaque spatial localization at a whole-brain scale. Using basic morphotypes (Diffuse, Core, Cerebral Amyloid Angiopathy) as a foundation, plaques are further clustered into 2, 5, 8, and 21 subtypes under feature groups including gray-level, shape, texture, and integrated multi features. Data were collected from five critical age groups—6 weeks, 2 months, 4 months, 6 months, and 10 months—employing consistent labeling, imaging, and processing protocols to ensure uniform data quality.
Based on this, we developed the PlaqueMap interactive platform, which includes:
- ·Labeled Aβ plaques on 2D registered coronal slices.
- ·3D visualization of plaques in the standard mouse brain.
- ·Statistical analysis results for all plaque types.
- ·Accompanying code for analytical framework available for download.
The platform will be continuously updated and expanded to meet the growing needs of the research community. In summary, PlaqueMap provides researchers with spatiotemporal insights into diverse plaque types in mice, offering reliable data and a valuable reference for Alzheimer's disease-related studies.
2D visualization
PlaqueMap provides 2D registered coronal slices displaying plaques categorized by basic morphotypes and clustered subtypes under various feature groups. The platform offers online browsing capabilities, encompassing 264 coronal planes, 228 sagittal planes, and 180 horizontal planes. Users can browse sequential slices within an orientation and switch freely among three standard profile directions. Each standard profile is presented as a 50-μm-thick projection image, overlaid with coordinate grids and annotated with boundaries of neuroanatomical structures.
3D visualization
PlaqueMap provides 3D visualizations of different plaque types within a standard mouse brain. Users can interactively explore the data from multiple viewing angles and at varying magnification levels.
Data statistical graph
Statistical results of the spatiotemporal distribution of different types of plaques.
Data and code availability
Provide imaging features, classification, and spatial localization of all plaques across age groups, along with complete analysis code.
